I recently moved from a Windows 7 machine to Windows 10 and when installing Xcelsius 4.1 SP 7, I had to revert to Office 2013 to get through the installation process.
Supposedly, there are workarounds that can get you through the installation such as creating dummy excel files then using later office versions, but I had no luck with any of them.
When opening XLF files, I get a server busy popup and have to switch to excel before my worksheet will load, but once I do that it seems to work fine.